An outbreak of eczema on the hands is painful and unpleasant. It can cause redness, itching, cracks, sores, blistering, and very dry, peeling skin. During an outbreak, the backs of the hands and fingers and the inside of the wrists may also be affected, and changes may also appear on the nails. Without proper treatment, eczema on the hands can become chronic. Daily tasks such as buttoning a button or working on a computer can become difficult. The formation of eczema on the hand is usually caused by several related causes, both genetics and contact allergens and irritants - environmental influences. Genetic predisposition makes some people more susceptible to external substances and allergens and more likely to develop hand eczema.